Hydrochloric Acid → HCID 23139213, compound

Participants

Reaction Steps

(E)-1-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-({2-[3-(ethoxycarbonyl)propyl]-2H-tetrazol-5-yl}methylidene}-4-sulfanylpiperidine hydrochloride (854 mg) was treated with 3 N aqueous hydrochloric acid solution (16 ml) at 50° C. for one hour in a similar manner to that described in Example 134. The reaction mixture was concentrated in vacuo, and the residue was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: acetonitrile/0.024 N aqueous hydrochloric acid, 30/70 to 35/65, v/v) to afford the title compound as a colourless amorphous solid (801 mg, yield: 99%).

Provenance & Evidence