Hydrochloric Acid → HCID 23139024, compound

Participants

Reaction Steps

Hydrogen chloride was passed through a solution of (E)-4-(acetylsulfanyl)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-({1-[3-(ethoxycarbonyl)propyl]-1H-tetrazol-5-yl}methylidene)piperidine (139 mg) in ethanol (4 ml) at 0° C. The mixture was stirred under tightly sealed condition at room temperature for 3.5 hours. The solvent and excess amount of hydrogen chloride were removed in vacuo, and the residue was purified by chromatography on silica gel using a mixture of ethanol and dichloromethane (2:98 to 12:88) as the eluent to afford the title compound as a pale yellow amorphous solid (136 mg, yield 99%)

Provenance & Evidence