Acetonitrile → HCID 23138606, compound

Participants

Reaction Steps

A solution of (E)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-({1-[3-(ethoxycarbonyl)propyl]-1H-tetrazol-5-yl}methylidene)-4-sulfanylpiperidine hydrochloride (134 mg) in 3 N HCl (4 ml) was stirred at 50° C. for 2 hours. The solvent and excess HCl were removed in vacuo, and the residue was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: acetonitrile/0.024 N aqueous HCl, 30/70, v/v) to afford the title compound as a colourless amorphous solid (91 mg, yield: 72%).

Provenance & Evidence