Hydrochloric Acid → HCID 23139165, compound

Participants

Reaction Steps

In a similar manner to that described in Example 133, (E)-4-(acetylsulfanyl)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-({1-[4-(ethoxycarbonyl)butyl]-1H-1,2,3-triazol-4-yl}methylidene)piperidine (1.32 g) was treated with hydrogen chloride. The crude product was purified by chromatography on silica gel using a mixture of methanol and dichloromethane (1:99 to 10:90) as the eluent to afford the title compound as a pale yellow amorphous solid (1.44 g, yield: 92%).

Provenance & Evidence