Acetic Anhydride → HCID 86609480, compound

Participants

Reaction Steps

In a similar manner to that described in Example 183, (E)-3-{[1-(4-carboxybutyl)-1H-1,2,3-triazol-4-yl]methylidene}-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-sulfanylpiperidine hydrochloride (190 mg) was treated with acetic anhydride. The crude product extracted using conventional procedures was purified by chromatography on silica gel using a mixture of methanol and dichloromethane (1:99 to 7:93) as the eluent to afford the title compound as a colourless oil (190 mg, yield: 99%).

Provenance & Evidence