Hydrochloric Acid → HCID 23139028, compound

Participants

Reaction Steps

To a solution of (E)-4-(acetylsulfanyl)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-({2-[3-(ethoxycarbonyl)propyl]-2H-1,2,3-triazol-4-yl}methylidene)piperidine (570 mg) in ethanol (50 ml) was introduced HCl gas at 0° C. for 30 minutes. The mixture was stirred under tightly sealed condition for 2 hours, and the solvent and excess hydrogen chloride were removed in vacuo. The residue was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: acetonitrile/0.024 N HCl, 35/65, v/v) to afford a fraction containing the product. This fraction was treated with a saturated aqueous sodium hydrogen carbonate solution, and the liberated base was extracted with ethyl acetate to afford the free base of the title compound.

Provenance & Evidence