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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1171782Generated: November 2, 2026

Acetic Acid → HCID 67068493, compound

https://huagongshe.com/reaction/1171782

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AcidHCID 176—
ReactantIndole-3-CarboxaldehydeHCID 10256—
ReactantEthyl 3-amino-1H-pyrrole-2-carboxylateHCID 2773439—
ReactantSodium cyanoborohydrideHCID 5003444—
SolventMethanolHCID 887—
ProductHCID 67068493HCID 67068493—

Reaction Steps

A reaction mixture of 3-amino-1H-pyrrole-2-carboxylic acid ethyl ester (0.075 g, 0.49 mmol), indole-3-carboxaldehyde (0.085 g, 0.58 mmol), NaCNBH3 (0.031 g, 0.49 mmol) and HOAc (0.056 mL, 0.97 mmol) in methanol (3 mL) was stirred at r.t. overnight. The mixture was concentrated in vacuo and the crude product-mixture was used in the next step without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07829707B2
Source datasetuspto-grants-2010_11
ORD IDord-56ac0a57f47e4556abd299b614bd1423
Source noteuspto-grants-2010_11