HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Isopropanol → Solifenacin
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Isopropanol | HCID 3776 | — |
| Edukt | 3-Quinuclidinol, (-)- | HCID 91404 | — |
| Edukt | Sodium | HCID 5360545 | — |
| Edukt | (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid propan-2-yl ester | HCID 67078773 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Lösungsmittel | 2-Propanol, sodium salt (1:1) | HCID 10920443 | — |
| Produkt | Solifenacin | HCID 154059 | 64,7% |
Reaktionsschritte
In a mixture of sodium isopropoxide prepared from 0.20 g of 2-propanol and 0.08 g of metallic sodium with 20 ml of toluene and 2.5 ml of DMF, 2.58 g of (R)-quinuclidin-3-ol was allowed to react with 5.00 g of (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid propan-2-yl ester for 8 hours while evaporating the solvent, thereby obtaining 3.97 g of a solifenacin-containing composition.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07829715B2 |
| Quelldatensatz | uspto-grants-2010_11 |
| ORD ID | ord-96d943b3aa024ce7998779cc47a6b581 |
| Quellennotiz | uspto-grants-2010_11 |