HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(Chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-(3-Methoxypropoxy)-3-methyl-2-pyridinemethanol | HCID 10465749 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 2-(Chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine | HCID 11031667 | 114.8% |
Reaction Steps
2-Hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine (5.0 g (23.7 mmol)) was dissolved in dimethoxyethane (40 ml), and thionyl chloride (4.23 g (35.6 mmol)) was added dropwise thereto so that the temperature did not exceed 25° C. Following stirring at room temperature, disappearance of the raw materials was confirmed by TLC, and 2-chloromethyl-4-(3-methoxypropoxy)-3-methylpyridine (6.25 g) was obtained by concentrating under a reduced pressure (yield: 99.2%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07829718B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-1a51cc911fb74898a0208cf132bb1998 |
| Source note | uspto-grants-2010_11 |