Water → Rabeprazole

HRID 1171863Notes

Reaction equation

HRID 1171863 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([CH2:13][S:14][C:15]2[NH:19][C:18]3[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=3[N:16]=2)[C:8]=1[CH3:24].[OH-:25].[Na+].O>ClCCl>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([CH2:13][S:14]([C:15]2[NH:16][C:17]3[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=3[N:19]=2)=[O:25])[C:8]=1[CH3:24]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 9949996Rabeprazole-thioether

Product 1

HCID 5029RabeprazoleYield 23.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-[{4-(3-Methoxypropoxy)-3-methylpyridin-2-yl}methylthio]-1H-benzimidazole (25.0 g (72.8 mmol)) was dissolved in dichloromethane and cooled. Then, mcpba (70.2% purity; 5.37 g (21.8 mmol)) was added gradually so that the internal temperature did not exceed −15° C. 10% Aqueous sodium hydroxide solution (70.8 ml) was then added, and after stirring and still standing the water layer was separated. The separated water layer was washed with dichloromethane (48 ml) twice. After addition of a 2N-ammonium acetate aqueous solution, the water layer was extracted with dichloromethane (48 ml) twice. The dichloromethane layer was washed with water (48 ml) twice, concentrated under a reduced pressure, crystallized with dichloromethane (14 ml) and acetonitrile (92 ml), and filtered to obtain 2-[{4-(3-methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole (6.26 g) (HPLC purity 99.7%, yield 23.9%).

Workup

  1. temperaturecooled
  2. additionThen, mcpba (70.2% purity; 5.37 g (21.8 mmol)) was added gradually so that the internal temperature
  3. customdid not exceed −15° C
  4. customwas separated
  5. washThe separated water layer was washed with dichloromethane (48 ml) twice
  6. additionAfter addition of a 2N-ammonium acetate aqueous solution
  7. extractionthe water layer was extracted with dichloromethane (48 ml) twice
  8. washThe dichloromethane layer was washed with water (48 ml) twice
  9. concentrationconcentrated under a reduced pressure
  10. customcrystallized with dichloromethane (14 ml) and acetonitrile (92 ml)
  11. filtrationfiltered

Sources & evidence

ORD record
ord-4174931adaae402193112b9ac7312f11
Source dataset
uspto-grants-2010_11
Patent number
US07829718B2

Reaction notes

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