Ethanol → HCID 86245030, compound

HRID 1171884Notes

Reaction equation

HRID 1171884 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH2:11][C:12]([OH:14])=[O:13].S(=O)(=O)(O)O.[CH2:20](O)[CH3:21]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH2:11][C:12]([O:14][CH2:20][CH3:21])=[O:13]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 687671652-Bromo-5-nitrobenzeneacetic acid

Product 1

HCID 86245030HCID 86245030, compound

Procedure

A mixture composed of 5.21 g (20 mmol) of (2-bromo-5-nitrophenyl)acetic acid (Zhumal Organicheskoi Khimii (1974) 10, 92-5), 80 ml of absolute ethanol and 0.1 ml of concentrated sulfuric acid is refluxed for 6 hours. After cooling, the reaction medium is concentrated under vacuum and taken up in ether. This organic phase is washed with saturated NaHCO3 solution and then with water, after which it is dried over Na2SO4. After concentrating under vacuum, 5.54 g of a beige solid are obtained.

Workup

  1. temperatureis refluxed for 6 hours
  2. temperatureAfter cooling
  3. concentrationthe reaction medium is concentrated under vacuum
  4. washThis organic phase is washed with saturated NaHCO3 solution
  5. dry with materialwith water, after which it is dried over Na2SO4
  6. concentrationAfter concentrating under vacuum, 5.54 g of a beige solid
  7. customare obtained

Sources & evidence

ORD record
ord-a0acd240f22f4725a8b2ef91f5abc032
Source dataset
uspto-grants-2010_11
Patent number
US07829721B2

Reaction notes

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