Ethanol → HCID 86245034, compound

HRID 1171885Notes

Reaction equation

HRID 1171885 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:4]([CH2:14][C:15]([OH:17])=[O:16])[CH:3]=1.S(=O)(=O)(O)O.[CH2:23](O)[CH3:24]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:4]([CH2:14][C:15]([O:17][CH2:23][CH3:24])=[O:16])[CH:3]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 46314660HCID 46314660, compound

Product 1

HCID 86245034HCID 86245034, compound

Procedure

A mixture composed of 900 mg (3.65 mmol) of (4-chlorobiphenyl-2-yl)acetic acid (J. Am. Chem. Soc. (1955), 77, 2325), 25 ml of absolute ethanol and 50 μl of concentrated sulfuric acid is refluxed for 8 hours. After cooling and concentrating under vacuum, the reaction medium is taken up in ether, washed with saturated NaHCO3 solution and then with water, and then dried over Na2SO4. After concentrating under vacuum, 1 g of a yellow oil is obtained.

Workup

  1. temperatureis refluxed for 8 hours
  2. temperatureAfter cooling
  3. concentrationconcentrating under vacuum
  4. washwashed with saturated NaHCO3 solution
  5. dry with materialwith water, and then dried over Na2SO4
  6. concentrationAfter concentrating under vacuum

Sources & evidence

ORD record
ord-d151a1dfe72c476c9f66e4cc578bd016
Source dataset
uspto-grants-2010_11
Patent number
US07829721B2

Reaction notes

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