Ammonia → HCID 11569260, compound

HRID 1171891Notes

Reaction equation

HRID 1171891 reaction equation
CO[C:3]1[C:6](=[O:7])[C:5](=[O:8])[C:4]=1[NH:9][C:10]1[CH:11]=[C:12]([NH:17][C:18]([C:20]2[S:21][CH:22]=[CH:23][C:24]=2[NH:25][CH2:26][C:27]2[C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[N:30]=[CH:29][CH:28]=2)=[O:19])[CH:13]=[CH:14][C:15]=1[CH3:16].[NH3:37]>>[NH2:37][C:3]1[C:6](=[O:7])[C:5](=[O:8])[C:4]=1[NH:9][C:10]1[CH:11]=[C:12]([NH:17][C:18]([C:20]2[S:21][CH:22]=[CH:23][C:24]=2[NH:25][CH2:26][C:27]2[C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[N:30]=[CH:29][CH:28]=2)=[O:19])[CH:13]=[CH:14][C:15]=1[CH3:16]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 11670524HCID 11670524, compound

Product 1

HCID 11569260HCID 11569260, compound

Procedure

EXAMPLE 45 was prepared according to the procedure described in EXAMPLE 3 using N-{3-[(2-methoxy-3,4-dioxocyclobut-1-en-1-yl)amino]4-methylphenyl}-3-[(quinolin-4-ylmethyl)amino]thiophene-2-carboxamide (EXAMPLE 44) and ammonia instead of dimethylamine. MS (ES+): m/z 483.9 [M+1]

Workup

  1. customEXAMPLE 45 was prepared

Sources & evidence

ORD record
ord-48f7073432624ce38786cd028e9f4949
Source dataset
uspto-grants-2010_11
Patent number
US07829717B2

Reaction notes

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