Sulfuric Acid → HCID 86601659, compound

Participants

Reaction Steps

The Form E3 is prepared by slurrying atazanavir free base in ethanol; treating the slurry with concentrated sulfuric acid employing a molar ratio of acid: free base with the range from about 1:1 to about 1.1:1, heating the resulting solution at from about 30 to about 40° C., seeding the solution with ethanol wet E3 crystals of atazanavir sulfate, treating the mixture with heptane (or other solvent such as hexane or toluene), filtering, and drying to yield atazanavir bisulfate Form E3 (triethanol solvate).

Provenance & Evidence