Water → 3-(5-Chloro-1-methyl-3-trifluoromethylpyrazol-4-ylmethanesulfonyl)-5,5-dimethyl-2-isoxazoline

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Reaction Steps

16.87 g of m-chloroperbenzoic acid (purity: 70%, 68.4 mmoles) was added, with ice-cooling, to a solution of 8.97 g (27.4 mmoles) of 3-(5-chloro-1-methyl-3-trifluoromethylpyrazol-4-ylmethylthio)-5,5-dimethyl-2-isoxazoline dissolved in 300 ml of chloroform. The mixture was stirred for 1 hour and then at room temperature over one night to give rise to a reaction. After the completion of the reaction, the reaction mixture was poured into water, followed by extraction with chloroform. The resulting organic layer was washed with an aqueous sodium hydrogensulfite solution, an aqueous sodium hydrogencarbonate solution, water and an aqueous sodium chloride solution in this order and then dried over anhydrous magnesium sulfate. The resulting solution was subjected to vacuum distillation to remove the solvent contained therein. The solid thus obtained was washed with n-hexane to obtain 9.36 g (yield: 95.1%) of 3-(5-chloro-1-methyl-3-trifluoromethylpyrazol-4-ylmethanesulfonyl)-5,5-dimethyl-2-isoxazoline as white powder (melting point: 115.0 to 116.0° C.).

Provenance & Evidence