HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 2-[(2-{(4S)-2-oxo-4-[(1E,4R)-8,8,8-trifluoro-4-hydroxy-4-methyl-1-octenyl]-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | (9S,13R)-13-methyl-13-(4,4,4-trifluorobutyl)-7,14-dioxa-2,18-dithia-5,19-diazatricyclo[14.2.1.05,9]nonadeca-1(19),10,16-triene-6,15-dione | HCID 66857374 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-[(2-{(4S)-2-oxo-4-[(1E,4R)-8,8,8-trifluoro-4-hydroxy-4-methyl-1-octenyl]-1,3-oxazolidin-3-yl}ethyl)sulfanyl]-1,3-thiazole-4-carboxylic acid | HCID 59554819 | — |
Reaction Steps
By the same procedure as the reaction of Example 8 using the compound 64-1 (Less polar) instead of the compound 7 and using a mixture of tetrahydrofuran and methanol instead of methanol, the title compound having the following physical data was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07833995B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-95262f1ce863407db8d5b822f6c09693 |
| Source note | uspto-grants-2010_11 |