HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1172212Generated: November 2, 2026
Potassium Carbonate → 4-[3-(4-Trifluoromethoxy-phenyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-sulfonyl]-indan-2-carboxylic acid methyl ester
https://huagongshe.com/reaction/1172212
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | methyl 4-(chlorosulfonyl)-2,3-dihydro-1H-indene-2-carboxylate | HCID 46835233 | — |
| Reactant | 3-(4-Trifluoromethoxy-phenyl)-3,9-diaza-bicyclo[3.3.1]nonane | HCID 67046014 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[3-(4-Trifluoromethoxy-phenyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-sulfonyl]-indan-2-carboxylic acid methyl ester | HCID 67045784 | — |
Reaction Steps
A mixture of 3-(4-trifluoromethoxy-phenyl)-3,9-diaza-bicyclo[3.3.1]nonane (60 mg, 0.21 mmol), 4-chlorosulfonyl-indan-2(R,S)-carboxylic acid methyl ester (120 mg, 0.44 mmol), potassium carbonate (200 mg, 1.4 mmol), and acetonitrile (3 mL) were heated at 50° C. for 2 h. The mixture was filtered through Celite, concentrated, and purified by silica gel chromatography (9:1→4:1; hexanes:ethyl acetate) to give 4-[3-(4-trifluoromethoxy-phenyl)-3,9-diaza-bicyclo[3.3.1]nonane-9-sulfonyl]-indan-2-carboxylic acid methyl ester: MS (ESI): 525.5 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07834004B2 |
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| Source dataset | uspto-grants-2010_11 |
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| ORD ID | ord-4dbb1001eb704658a8e917968bd08d34 |
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| Source note | uspto-grants-2010_11 |
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