反应详情

温度

40 °C

Methyl 2-(3-chloropropoxy)indole-3-carboxylate (5.0 g, 18.7 mmol) was added to a stirred mixture of 5.4 M aqueous M NaOH (3.8 ml) and toluene (50 ml) and heated at 40° C. for 4 h. The aqueous layer was separated and the organic layer washed with H2O (3×25 ml) while maintaining the temperature at 60° C. The organic solvent was evaporated in vacuo to leave the product as a white solid (4.0 g, 93.2%).

1. customThe aqueous layer was separated
2. washthe organic layer washed with H2O (3×25 ml)
3. temperaturewhile maintaining the temperature at 60° C
4. customThe organic solvent was evaporated in vacuo