Ethanol → Ethyl 2-(3-isopentyl-4-oxo-2-phenylthiazolidin-5-yl)acetate

HRID 1172303Notes

Reaction equation

HRID 1172303 reaction equation
[CH2:1]([N:6]1[C:10](=[O:11])[CH:9]([CH2:12][C:13]([OH:15])=[O:14])[S:8][CH:7]1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH2:2][CH:3]([CH3:5])[CH3:4].[CH3:22][CH2:23]O>OS(O)(=O)=O>[CH2:1]([N:6]1[C:10](=[O:11])[CH:9]([CH2:12][C:13]([O:15][CH2:22][CH3:23])=[O:14])[S:8][CH:7]1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH2:2][CH:3]([CH3:5])[CH3:4]

Participants

4

Reactant 2

HCID 702EthanolHCID 59555275HCID 59555275, compound

Product 1

HCID 59554901Ethyl 2-(3-isopentyl-4-oxo-2-phenylthiazolidin-5-yl)acetate

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

A solution of 2-(3-Isopentyl-4-oxo-2-phenylthiazolidin-5-yl)acetic acid (2.2 g, 7.2 mmol) in EtOH (20 ml) and H2SO4 (1 ml) was refluxed for 16 hours. The solution was evaporated to dryness and the residue was taken up in EtOAc and washed with sat. aq. Na2CO3 (3×), brine and evaporated to give the desired product as an oil.

Workup

  1. customThe solution was evaporated to dryness
  2. washwashed with sat. aq. Na2CO3 (3×), brine
  3. customevaporated

Sources & evidence

ORD record
ord-aea00943ff6049caa95f4a8cd7d293dc
Source dataset
uspto-grants-2010_11
Patent number
US07834000B2

Reaction notes

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