HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 3-(1-(2-(3-Isopentyl-4-oxo-2-phenylthiazolidin-5-yl)propanoyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 2-(3-Isopentyl-4-oxo-2-phenylthiazolidin-5-yl)propanoic acid | HCID 59554951 | — |
| Reactant | 3,4-dihydro-3-(piperidin-4-yl)quinazolin-2(1H)-one TFA | HCID 69187553 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(1-(2-(3-Isopentyl-4-oxo-2-phenylthiazolidin-5-yl)propanoyl)piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one | HCID 59554902 | — |
Reaction Steps
To a solution of 2-(3-Isopentyl-4-oxo-2-phenylthiazolidin-5-yl)propanoic acid (11 mg, 0.034 mmol), 3,4-Dihydro-3-(piperidin-4-yl)quinazolin-2(1H)-one TFA (17 mg, 0.051 mmol) and DiPEA (24 ul, 0.14 mmol) in DMF (0.2 ml) was added HATU (17 mg, 0.044 mmol) and the reaction mixture was stirred at RT for 16 hours. Purification by preparative reverse phase HPLC using 10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA) gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07834000B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-b8fea75e067c43f5a322a91a454413e3 |
| Source note | uspto-grants-2010_11 |