Hydrochloric Acid → HCID 68772019, compound

Participants

Reaction Steps

To a solution of Example 2A (100 mg, 0.037 mmol) in a 2 mL solution of 1:1 aqueous concentrated HCl in methanol at 0° C., Zn dust (32 mg, 0.5 mmol) was added in several portions. The solution was allowed to warm to room temperature over three hours, after which the solution was carefully basified with saturated NaHCO3. The mixture was extracted with ethyl acetate, concentrated, taken up in dichloromethane, and filtered through Celite. Concentration of the filtrate gave the title compound. 1H NMR (300 MHz, C5D5N) δ ppm 7.48 (s, 1H), 7.31-7.33 (m, 2H), 5.68-5.73 (m, 2H), 3.28-3.37 (m, 2H), 2.45-2.49 (m, 1H), 2.29-2.36 (m, 1H), 2.06-2.13 (m, 2H). MS (ESI+) m/z 243 (M+H)+.

Provenance & Evidence