HCID 68769641, compound → HCID 68768163, compound

Participants

Reaction Steps

To a solution of Example 9A (35 mg, 0.068 mmol) in mixture of methanol/acetic acid (0.5 mL/0.5 mL) Zn powder (45 mg, 0.68 mmol) was added at room temperature. The reaction mixture was stirred for thirty minutes, filtered, concentrated under reduced pressure and purified by high-pressure liquid chromotography (eluting with 0-70% acetonitrile/water and 0.1% trifluoroacetic acid) to provide the title compound (25 mg, 76%). 1H NMR (400 MHz, DMSO-d6) δ ppm 8.54-8.72 (m, 1H), 7.89-8.11 (m, 2H), 6.96-7.72 (m, 8H), 4.46-4.58 (m, 2H), 3.80-3.87 (m, 4H), 3.59-3.72 (m, 1H), 2.53-2.88 (m, 4H). MS (ESI) m/z 483 (M+H)+.

Provenance & Evidence