HCID 68772134, compound → HCID 68774314, compound

Participants

Reaction Steps

To a solution of Example 11B (60 mg, 0.136 mmol) in mixture of methanol/acetic acid (0.5 mL/0.5 mL), Zn powder (89 mg, 1.36 mmol) was added at room temperature. The reaction mixture was stirred for thirty minutes, filtered, concentrated under reduced pressure and purified by high pressure liquid chromotography (eluting with 0-70% acetonitrile/water and 0.1% trifluoroacetic acid) to provide the title compound (50 mg, 89%). 1H NMR (400 MHz, DMSO-d6) δ ppm 7.85-8.03 (m, 3H), 7.66 (s, 1H), 7.46-7.61 (m, 2H), 5.97-6.16 (m, 1H), 4.02-4.22 (m, 2H), 3.65-3.95 (m, 3H), 2.82-3.04 (m, 2H), 1.68-2.69 (m, 13H), 1.12-1.29 (m, 3H). MS (ESI) m/z 411 (M+H)+.

Provenance & Evidence