Hydrochloric Acid → HCID 68767718, compound

Participants

Reaction Steps

To a solution of Example 11C (36 mg, 0.088 mmol) in mixture of tetrahydrofuran/H2O (0.3 mL/0.15 mL), LiOH (23 mg, 0.53 mmol) was added at room temperature. The reaction mixture was stirred overnight. It was acidified with 2N HCl in ether until pH=3 and purified by high pressure liquid chromotography (eluting with 0-70% acetonitrile/water and 0.1% trifluoroacetic acid) to provide the title compound (25 mg, 75%). 1H NMR (500 MHz, DMSO-d6) δ ppm 7.90-8.07 (m, 3H), 7.67 (s, 1H), 7.47-7.58 (m, 2H), 6.01-6.14 (m, 1H), 3.66-3.96 (m, 2H), 2.57-3.04 (m, 4H), 1.65-2.46 (m, 9H). MS (ESI) m/z 383 (M+H)+.

Provenance & Evidence