HCID 16058857, compound → HCID 16058858, compound

HRID 1172372Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]([CH2:11][C@@H:12]([NH:43][C:44]([N:46]2[CH2:51][CH2:50][CH:49]([N:52]3[CH2:61][C:60]4[C:55](=[CH:56][CH:57]=[CH:58][CH:59]=4)[NH:54][C:53]3=[O:62])[CH2:48][CH2:47]2)=[O:45])[C:13]([NH:15][C@H:16]([C:29](=[O:42])[N:30]2[CH2:35][CH2:34][N:33]([C:36]3[CH:41]=[CH:40][N:39]=[CH:38][CH:37]=3)[CH2:32][CH2:31]2)[CH2:17][CH2:18][CH2:19][CH2:20][NH:21]C(=O)OC(C)(C)C)=[O:14])[CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[CH:7]2.NCCCC[C@H](NC(=O)[C@H](NC(N1CCC(C2C(=O)NC3C(C=2)=CC=CC=3)CC1)=O)CC1C=C2C(=C(C)C=1)NN=C2)C(=O)N1CCN(C2C=CN=CC=2)CC1>>[NH2:21][CH2:20][CH2:19][CH2:18][CH2:17][C@H:16]([NH:15][C:13](=[O:14])[C@H:12]([NH:43][C:44]([N:46]1[CH2:51][CH2:50][CH:49]([N:52]2[CH2:61][C:60]3[C:55](=[CH:56][CH:57]=[CH:58][CH:59]=3)[NH:54][C:53]2=[O:62])[CH2:48][CH2:47]1)=[O:45])[CH2:11][C:4]1[CH:5]=[C:6]2[C:10](=[C:2]([CH3:1])[CH:3]=1)[NH:9][N:8]=[CH:7]2)[C:29](=[O:42])[N:30]1[CH2:35][CH2:34][N:33]([C:36]2[CH:41]=[CH:40][N:39]=[CH:38][CH:37]=2)[CH2:32][CH2:31]1

Participants

Reactant 2

HCID 16058857HCID 16058857, compound

HCID 16058859HCID 16058859, compound

Product 1

HCID 16058858HCID 16058858, compound

Procedure

The title compound was prepared from tert-Butyl (S)-5-((R)-3-(7-methyl-1H-indazol-5-yl)-2-(4-(2-oxo-1,2-dihydroquinazolin-3 (4H)-yl)piperidine-1-carboxamido)propanamido)-6-oxo-6-(4-(pyridin-4-yl)piperazin-1-yl)hexylcarbamate using the same procedure as described for N-((R)-1-((S)-6-amino-1-oxo-1-(4-(pyridin-4-yl)piperazin-1-yl)hexan-2-ylamino)-3-(7-methyl-1H-indazol-5-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide. The title compound was obtained in 70% yield. MS (ESI) 750 (M+H) ; Rf=1.58.

Sources & evidence

ORD record: ord-ab864958cace4d48b9351e9f47409f1d
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07834007B2

Reaction notes

Loading…