1,4-Dioxane hydrochloride → HCID 86604995, compound

HRID 1172443Notes

Reaction equation

HRID 1172443 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][N:14]2[CH2:19][CH2:18][N:17]([C:20](=[O:29])[C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:22]=3[F:28])[CH2:16][CH2:15]2)[N:8]=1.[ClH:30].O1CCOCC1>CO>[ClH:30].[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][N:14]2[CH2:15][CH2:16][N:17]([C:20](=[O:29])[C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:22]=3[F:28])[CH2:18][CH2:19]2)[N:8]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57562600HCID 57562600, compound

Product 1

HCID 86604995HCID 86604995, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 293 mg of (thiazol-2-yl)-(6-(4-(2,3-difluorobenzoyl)-piperazin-1-ylmethyl)-pyridin-2-yl)-amine (Example 4) with 1 ml of methanol was charged with a hydrochloric acid-1,4-dioxane solution (4 M, 3 ml), followed by stirring at room temperature for 1 hour. The reaction mixture was concentrated in vacuo and the residue was suspended in diethyl ether, filtered and collected to give the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. filtrationfiltered
  3. customcollected

Sources & evidence

ORD record
ord-4de3abcc0ee04b6e8126f07820993185
Source dataset
uspto-grants-2010_11
Patent number
US07834018B2

Reaction notes

Loading…