1,4-Dioxane hydrochloride → 1-(3-Chloro-2-fluorobenzoyl)piperazine hydrochloride

Participants

Reaction Steps

To a mixture of 35.1 g of tert-butyl 4-(3-chloro-2-fluorobenzoyl)piperazine-1-carboxylate and 50 ml of methanol was added a hydrochloric acid-1,4-dioxane solution (4 M, 100 ml) followed by stirring at room temperature for 2.5 hours. The reaction mixture was concentrated in vacuo and the residue was suspended in diethyl ether, filtered and collected to give the title compound.

Provenance & Evidence