Water → HCID 131728444, compound

Participants

Reaction Steps

A mixture of Example 49j (0.2 g, 0.45 mmol) and 1-methyl-piperazine (0.08 mL, 0.9 mmol) in dry ethyl acetate was stirred overnight at 25° C., treated with water and extracted with ethyl acetate. The organic layer was washed with dil aqueous HCl (10%, 50 mL), water, brine, concentrated and purified using flash chromatography (silica gel, methanol/chloroform) to obtain the title compound. Yield: 0.180 g, (80%) 1H NMR (DMSO-d6): δ 2.20 (s, 3H, CH3), 2.30 (s, 4H, CH2), 2.80 (s, 3H, CH3), 3.00 (s, 4H, CH2), 5.40 (s, 2H, CH2), 8.00 (s, 1H, Ar), 8.10 (s, 1H, Ar), 8.20 (s, 2H, Ar). MS: m/e (ES+) 501 (M+).

Provenance & Evidence