Methanol → HCID 131728494, compound

Participants

Reaction Steps

Thiophenemethylamine (0.5 g 4.41 mmol) was added to a solution of Example 102j (0.6 g, 1.25 mmol) in methanol (10 mL), followed by the addition of n-tetrabutylammonium iodide (0.010 g, 0.027 mmol) in an atmosphere of nitrogen and sealed in a pressure reactor vessel at 110° C. for 6 h. It was processed as described in the synthesis of Example 129k to obtain the title compound as a white solid. Yield: 0.370 g, (55.38%); 1H NMR (DMSO-d6): δ 2.55-2.60 (m, 4H, 2CH2), 2.70 (s, 3H, CH3), 3.20-3.55 (m, 4H, 2CH2), 3.75 (s, 3H, CH3), 3.95 (s, 3H, OCH3), 4.65 (s, 2H, CH2), 6.75 (s, 1H, Ar), 6.90 (s, 1H, Ar), 6.95-7.05 (m, 2H, Ar), 7.30 (s, 1H, Ar), 8.10 (s, 1H, Ar), 8.40 (s, 1H, Ar); MS: m/e (CI+) 533 (M+1).

Provenance & Evidence