Potassium Carbonate → HCID 131728509, compound

Participants

Reaction Steps

A mixture of Example 155a (2.0 g, 4.99 mmol) and anhydrous potassium carbonate (1.38 g, 9.99 mmol) in dry DMF (25 mL) was heated at 95° C. for 20 h. The reaction mixture was concentrated treated with water, 10% aqueous HCl solution and extracted with 1-butanol. The organic layer was washed with water, brine, dried, concentrated and purified using flash chromatography (silica gel, 2.5% methanol/chloroform) to obtain the title compound. Yield: 0.9 g, (56.4%) 1H NMR (DMSO-d6): δ 2.4 (s, 3H, CH3), 3.9 (s, 3H, OCH3), 7.1 (m, 1H, Ar), 7.2 (m, 2H, Ar), 7.48 (m, 1H, Ar), 8.1 (s, 1H, Ar), 11.1 (s, 1H, NH); MS: m/e (ES+) 320 (M+1).

Provenance & Evidence