Morpholine → HCID 131728510, compound

Participants

Reaction Conditions

Reaction Steps

Morpholine (0.2 mL, 2.52 mmol) was added to a solution of Example 160 (0.5 g, 1.26 mmol) in dry dimethylformamide (10 mL) and the reaction mixture was stirred at 110° C. for 3 h. It was concentrated, treated with water and the solid that precipitated was filtered, washed with water, dried and purified using flash chromatography (silica gel, methanol/chloroform) to obtain the title compound as a white solid. Yield: 0.5 g, (88.80%); 1H NMR (DMSO-d6): δ 2.35-2.45 (m, 4H, 2CH2), 2.60-2.70 (m, 4H, 2CH2), 2.80 (s, 3H, CH3), 3.10-3.20 (m, 2H, CH2), 3.55-3.60 (m, 2H, CH2), 3.90 (s, 3H, OCH3), 5.10 (s, 2H, CH2), 6.70-6.85 (m, 2H, Ar), 7.20 (t, 1H, Ar), 8.10 (s, 1H, Ar), 8.25 (s, 1H, Ar); MS: m/e (EI+) 446 (M+1).

Provenance & Evidence