alpha-Bromo-2-nitrotoluene → HCID 68427056, compound

HRID 1172547Notes

Reaction equation

HRID 1172547 reaction equation
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([Br:10])=[C:6]([SH:11])[CH:5]=1.Br[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N+:21]([O-:23])=[O:22]>>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([Br:10])=[C:6]([S:11][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[N+:21]([O-:23])=[O:22])[CH:5]=1

Participants

3

Reactant 2

HCID 77569alpha-Bromo-2-nitrotolueneHCID 68425140HCID 68425140, compound

Product 1

HCID 68427056HCID 68427056, compound

Procedure

4-Bromo-3-mercapto-benzoic acid methyl ester was reacted with 1-bromomethyl-2-nitro-benzene as described in the synthesis of Example 1f to obtain the title compound. Yield: (64%); 1H NMR (CDCl3): δ 3.90 (s, 3H, OCH3), 4.55 (s, 2H, CH2), 7.40-7.55 (m, 3H, Ar), 7.60 (d, 1H, Ar), 7.70 (d, 1H, Ar), 7.90 (d, 1H, Ar), 8.10 (d, 1H, Ar).

Workup

  1. customas described in the synthesis of Example 1f

Sources & evidence

ORD record
ord-e6881ebcc1b3423c897a1414e898c3cc
Source dataset
uspto-grants-2010_11
Patent number
US07834001B2

Reaction notes

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