Azide → HCID 86613762, compound

Participants

Reaction Steps

7-Hydroxymethyl-octahydro-pyrido[1,2-a]pyrazine-2-carboxylic acid tert-butyl ester (see subpart (a) above), was converted to the corresponding mesylate, azide and amine sequentially according to Example 6, subparts (b)-(d) above. The corresponding amine was coupled to 2-furan-2-yl-5-methanesulfonyl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ylamine in accordance to Example 1 to afford trans-7-[(7-amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)-methyl]-octahydro-pyrido[1,2-a]pyrazine-2-carboxylic acid tert-butyl ester as yellow oil. This material was used in the next step without further purification.

Provenance & Evidence