Ammonia → HCID 57659603, compound

HRID 1172583Notes

Reaction equation

HRID 1172583 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]1[N:6]([CH2:11][CH3:12])[N:7]=[C:8]([CH3:10])[CH:9]=1.CO.[NH3:16]>>[CH2:11]([N:6]1[C:5]([CH2:4][C:3]([NH2:16])=[O:2])=[CH:9][C:8]([CH3:10])=[N:7]1)[CH3:12]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 887MethanolHCID 17830179HCID 17830179, compound

Product 1

HCID 57659603HCID 57659603, compound

Procedure

(2-Ethyl-5-methyl-2H-pyrazol-3-yl)-acetic acid methyl ester (4.64 g, 25.46 mmol) was dissolved in 7N ammonia in methanol (100 ml, 700 mmol NH3). The reaction mixture was stirred at rt for 20 h. The solvent was removed under reduced pressure to give 4.25 g (quant. yield) of 2-(2-ethyl-5-methyl-2H-pyrazol-3-yl)-acetamide. LC-MS: tR=0.33 min; [M+H]+=no ionisation.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-9a8b56a2854340249b8cf6b5b42ab862
Source dataset
uspto-grants-2010_11
Patent number
US07834028B2

Reaction notes

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