3-(Trifluoromethyl)benzenepropanal → Benzenepropanol, 3-(trifluoromethyl)-

HRID 1172595Notes

Reaction equation

HRID 1172595 reaction equation
FC(F)(F)C1C=CC(CCC=O)=CC=1.C1C=C[NH+]=CC=1.[O-][Cr](Cl)(=O)=O.[F:26][C:27]([F:39])([F:38])[C:28]1[CH:29]=[C:30]([CH2:34][CH2:35][CH:36]=[O:37])[CH:31]=[CH:32][CH:33]=1>>[F:26][C:27]([F:38])([F:39])[C:28]1[CH:29]=[C:30]([CH2:34][CH2:35][CH2:36][OH:37])[CH:31]=[CH:32][CH:33]=1

Participants

4

Reactant 3

HCID 112986123-(Trifluoromethyl)benzenepropanalHCID 216838073-[4-(Trifluoromethyl)phenyl]propanalHCID 178418287HCID 178418287, compound

Product 1

HCID 18755618Benzenepropanol, 3-(trifluoromethyl)-Yield 229.7%

Procedure

According to the procedure described above for the preparation of 3-(4-trifluoromethyl-phenyl)-propionaldehyde by PCC-oxidation, 132 mg (44%) of 3-(3-trifluoromethyl-phenyl)-propionaldehyde {LC-MS: tR=0.89 min; [M+H]+=no ionization} was obtained from 3-(3-trifluoromethyl-phenyl)-propan-1-ol (300 mg, 1.5 mmol).

Sources & evidence

ORD record
ord-614224a9f936432585ee6de70b49f0b3
Source dataset
uspto-grants-2010_11
Patent number
US07834028B2

Reaction notes

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