HuagongsheHuagongshe Chemistry Print Report · For research reference only
Borane → 2-Fluoro-3-methylbenzenepropanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Borane | HCID 6331 | — |
| Reactant | 955403-63-1 | HCID 57659614 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Fluoro-3-methylbenzenepropanol | HCID 57659610 | 82.5% |
Reaction Steps
According to procedures described above, 3-(2-fluoro-3-methyl-phenyl)-propionic acid (2.39 g, 13.12 mmol) was reduced by borane in THF to give 1.82 g (82.5%) of 3-(2-fluoro-3-methyl-phenyl)-propan-1-ol. LC-MS: tR=0.86 min; [M+H]+=no ionization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07834028B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-643e7bf0ed9b4038a6591460dbe114d9 |
| Source note | uspto-grants-2010_11 |