HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiomorpholine → 4-(2-Methyl-4-nitrophenyl)thiomorpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiomorpholine | HCID 67164 | — |
| Reactant | Benzene, 1-fluoro-2-methyl-4-nitro- | HCID 68001 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-(2-Methyl-4-nitrophenyl)thiomorpholine | HCID 67171237 | — |
Reaction Steps
In the same manner as in Production Example 5-1, but using thiomorpholine in place of N-ethylpiperazine used in Production Example 5-1, using 5-nitro-2-fluorotoluene in place of 2-fluoro-5-nitrobenzyl alcohol, using N,N-diisopropylethylamine in place of potassium carbonate, and using dimethylsulfoxide in place of N-methylpyrrolidone, crude 4-(2-methyl-4-nitrophenyl)thiomorpholine was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07834019B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-b54b05150de34e52bde78c13ae7c4553 |
| Source note | uspto-grants-2010_11 |