HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Epoxy-3-fluoropropane → 1-Fluoro-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Epoxy-3-fluoropropane | HCID 10418 | — |
| Reactant | 1-(4-Nitrophenyl)piperazine | HCID 80447 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Fluoro-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-ol | HCID 67171089 | 43.9% |
Reaction Steps
Ethanol (15 mL) solution of 272 mg of epifluorohydrin and 500 mg of 1-(4-nitrophenyl)piperazine was heated under reflux for 15 hours, and then the reaction liquid was concentrated under reduced pressure. The residue was solidified from ethyl acetate to obtain 300 mg of the entitled compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07834019B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-a96acaf4421942fbb6db7b3ca2629fde |
| Source note | uspto-grants-2010_11 |