反应详情

To a solution of 1 g of [[2-(4-trifluoromethyl-phenyl)-4-(4-trifluoromethyl-piperidin-1-ylmethyl)-thiazol-5-yl]-methanol in 7 ml of dichloromethane was added 2.35 g of manganese(IV)oxide (activated with charcoal). The resulting mixture was heated under reflux for four hours. The cooled reaction mixture was filtered through a pad of celite. The filtrate was concentrated under reduced pressure and purified by column chromatography on silica gel (heptane 80/ethyl acetate 20) to give 0.53 g of 2-(4-trifluoromethyl-phenyl)-4-(4-trifluoromethyl-piperidin-1-ylmethyl)-thiazole-5-carbaldehyde.

1. temperatureThe resulting mixture was heated
2. temperatureunder reflux for four hours
3. customThe cooled reaction mixture
4. filtrationwas filtered through a pad of celite
5. concentrationThe filtrate was concentrated under reduced pressure
6. custompurified by column chromatography on silica gel (heptane 80/ethyl acetate 20)