Triethyl phosphite → HCID 59556333, compound

HRID 1172689Notes

Reaction equation

HRID 1172689 reaction equation
Br[CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[C:5]([F:11])[CH:4]=1.[P:12]([O:19]CC)([O:16][CH2:17][CH3:18])[O:13][CH2:14][CH3:15]>>[CH2:14]([O:13][P:12]([CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[C:5]([F:11])[CH:4]=1)(=[O:19])[O:16][CH2:17][CH3:18])[CH3:15]

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 27784664-Cyano-3-fluorobenzyl bromide

Product 1

HCID 59556333HCID 59556333, compound

Conditions

Temperature
150 °C

Procedure

2.2 g 4-Bromomethyl-2-fluoro-benzonitrile were dissolved in 2.0 ml triethyl phosphite and stirred at 150° C. for four hours. Then the triethyl phosphite was removed in vacuo to obtain 2.5 g (4-Cyano-3-fluoro-benzyl)-phosphonic acid diethyl ester as an oil.

Workup

  1. customThen the triethyl phosphite was removed in vacuo

Sources & evidence

ORD record
ord-44560fe2d2d3453ebba2222b72129de2
Source dataset
uspto-grants-2010_11
Patent number
US07834030B2

Reaction notes

Loading…