反应详情

2.0 g (7.2 mmol) of 5-bromo-1-methyl-2-phenyl-1H-benzimidazole, 1.2 g (7.9 mmol) of 4-chlorophenylboronic acid, and 0.17 g (0.14 mmol) of tetrakis(triphenylphosphine)palladium were dissolved into 20 mL of 1,2-dimethoxyethane. Then, 10 mL of a 2 M aqueous solution of sodium carbonate were added, and the whole was refluxed under heating for 8 hours in an argon atmosphere. After the resultant had been stood to cool, an aqueous layer was removed and an organic layer was dried with magnesium sulfate. After the solvent had been distilled off under reduced pressure, the resultant solid was purified by means of silica gel column chromatography to obtain 2.0 g of 5-(4-chlorophenyl)-1,2-diphenyl-1H-benzimidazole (87% yield).

1. temperaturethe whole was refluxed
2. temperatureunder heating for 8 hours in an argon atmosphere
3. temperatureto cool
4. customan aqueous layer was removed
5. dry with materialan organic layer was dried with magnesium sulfate
6. distillationAfter the solvent had been distilled off under reduced pressure
7. customthe resultant solid was purified by means of silica gel column chromatography