HCID 68689700, compound → HCID 68685883, compound

Participants

Reaction Conditions

Reaction Steps

A solution of A3 (1 eq) in a mixture of DCM and TFA (2:1) was heated in a microwave oven at 120° C. for 10 min. The reaction mixture was diluted with DCM and toluene and concentrated under reduced pressure. The resulting crude was diluted with DCM and washed with sat. aq. NaHCO3 solution, dried (Na2SO4) and concentrated under reduced pressure. The resulting crude was purified by Biotage system eluting with EtOAc/petrol ether to obtain the desired compound. MS (ES) C15H10FN3O requires: 267, found: 268 (M+H)+. 1H NMR (400 MHz, DMSO-d6) δ: 10.51 (1H, d, J=5.3 Hz), 7.97 (1H, dd, J=6.3, 2.0 Hz), 7.79-7.72 (1H, m), 7.47 (1H, t, J=9.0 Hz), 7.34-7.30 (1H, m), 6.92-6.88 (1H, m), 6.54-6.49 (2H, m), 4.08 (2H, s).

Provenance & Evidence