Glyoxylic Acid → HCID 86633431, compound

HRID 1172801Notes

Reaction equation

[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[Cl:8][C:9]1[N:13]2[C:14]([CH2:19][C:20]3[CH:21]=[CH:22][C:23]([F:35])=[C:24]([CH:34]=3)[C:25]([N:27]3[CH2:33][CH2:32][CH2:31][NH2+:30][CH2:29][CH2:28]3)=[O:26])=[CH:15][NH:16][C:17](=[O:18])[C:12]2=[CH:11][C:10]=1[Cl:36].[C:37]([OH:41])(=[O:40])[CH:38]=O>>[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[C:37]([CH2:38][NH+:30]1[CH2:31][CH2:32][CH2:33][N:27]([C:25](=[O:26])[C:24]2[CH:34]=[C:20]([CH2:19][C:14]3[N:13]4[C:9]([Cl:8])=[C:10]([Cl:36])[CH:11]=[C:12]4[C:17](=[O:18])[NH:16][CH:15]=3)[CH:21]=[CH:22][C:23]=2[F:35])[CH2:28][CH2:29]1)([OH:41])=[O:40]

Participants

Reactant 2

HCID 760Glyoxylic Acid

HCID 86633433HCID 86633433, compound

Product 1

HCID 86633431HCID 86633431, compound

Procedure

The title compound was prepared as described in Example 2 from Example 8, H3 and glyoxylic acid. 1H NMR (300 MHz, DMSO-d6) δ: 10.96 (1H, d, J=5.6 Hz), 7.37-7.19 (4H, m), 6.64-6.61 (1H, m), 4.42 (2H, s), 4.20 (2H, s), 4.05-3.25 (8H, m), 2.17-1.99 (2H, m). MS (ES) C22H21Cl2FN4O4 required: 494, found: 495 (M+H)+.

Sources & evidence

ORD record: ord-deca07b7d2604a6694b7ba9f24cffada
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07834015B2

Reaction notes

Loading…