反应详情

To a solution of the product from Step 7 (1.2 g, 4.2 mmol) in dioxane (20 mL) at room temperature was added dropwise bromine (0.25 mL, 5.0 mmol). After 2 h at room temperature, the reaction mixture was diluted with ethyl acetate, washed with an aqueous solution of sodium thiosulfate and dried over magnesium sulfate. Removal of the solvent gave a residue which was purified by chromatography on silica gel to give the title product.

1. washwashed with an aqueous solution of sodium thiosulfate
2. dry with materialdried over magnesium sulfate
3. customRemoval of the solvent
4. customgave a residue which
5. customwas purified by chromatography on silica gel