Bromine → 2-Bromo-1-[4-(4-chlorophenoxy)-2-propylphenyl]ethanone

HRID 1172812노트

반응식

HRID 1172812 반응식
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[C:9]([CH2:16][CH2:17][CH3:18])[CH:8]=2)=[CH:4][CH:3]=1.[Br:21]Br>O1CCOCC1.C(OCC)(=O)C>[Br:21][CH2:14][C:13]([C:10]1[CH:11]=[CH:12][C:7]([O:6][C:5]2[CH:19]=[CH:20][C:2]([Cl:1])=[CH:3][CH:4]=2)=[CH:8][C:9]=1[CH2:16][CH2:17][CH3:18])=[O:15]

참가 물질

5

반응물 2

HCID 24408BromineHCID 574201401-[4-(4-Chlorophenoxy)-2-propylphenyl]ethanone

생성물 1

HCID 574201412-Bromo-1-[4-(4-chlorophenoxy)-2-propylphenyl]ethanone

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 312751,4-Dioxane용매

실험 절차

To a solution of the product from Step 7 (1.2 g, 4.2 mmol) in dioxane (20 mL) at room temperature was added dropwise bromine (0.25 mL, 5.0 mmol). After 2 h at room temperature, the reaction mixture was diluted with ethyl acetate, washed with an aqueous solution of sodium thiosulfate and dried over magnesium sulfate. Removal of the solvent gave a residue which was purified by chromatography on silica gel to give the title product.

후처리

  1. washwashed with an aqueous solution of sodium thiosulfate
  2. dry with materialdried over magnesium sulfate
  3. customRemoval of the solvent
  4. customgave a residue which
  5. customwas purified by chromatography on silica gel

출처 및 근거

ORD 기록
ord-4a0aca9f0f9142fd82b0edbabff23fc3
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834036B2

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