Boron tribromide → 3-[4-(4-Chlorophenoxy)-2-propylphenyl]-1-benzofuran-5-ol

Participants

Reaction Steps

To a solution of the product from Step 10 (0.34 g, 0.86 mmol) in dichloromethane (5.0 mL) cooled with an ice bath was added boron tribromide (1.0 M in dichloromethane, 1.7 mL, 1.7 mmol). The reaction mixture was gradually warmed to room temperature over 1 h, diluted with ethyl acetate and poured into a saturated solution of sodium bicarbonate. The organic layer was washed with brine, dried and filtered through a short path of silica gel to give the title product.

Provenance & Evidence