(+)-Methyl lactate → (2S)-2-({3-[4-(4-chlorophenoxy)-2-propylphenyl]-1-benzofuran-5-yl}oxy)propanoic acid

HRID 1172816Notes

Reaction equation

HRID 1172816 reaction equation
[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([C:13]3[C:17]4[CH:18]=[C:19]([OH:22])[CH:20]=[CH:21][C:16]=4[O:15][CH:14]=3)=[C:9]([CH2:23][CH2:24][CH3:25])[CH:8]=2)=[CH:4][CH:3]=1.[C:28]([O:33]C)(=[O:32])[C@@H:29]([CH3:31])O>>[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([C:13]3[C:17]4[CH:18]=[C:19]([O:22][C@@H:29]([CH3:31])[C:28]([OH:33])=[O:32])[CH:20]=[CH:21][C:16]=4[O:15][CH:14]=3)=[C:9]([CH2:23][CH2:24][CH3:25])[CH:8]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 637514(+)-Methyl lactateHCID 574201423-[4-(4-Chlorophenoxy)-2-propylphenyl]-1-benzofuran-5-ol

Product 1

HCID 11597597(2S)-2-({3-[4-(4-chlorophenoxy)-2-propylphenyl]-1-benzofuran-5-yl}oxy)propanoic acid

Procedure

The title compound was prepared according to the following general procedure using the phenol from Step 11 and methyl (R)-lactate as the substrates.

Sources & evidence

ORD record
ord-03a59e2615744f0687e01e68b5ba338a
Source dataset
uspto-grants-2010_11
Patent number
US07834036B2

Reaction notes

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