Diisobutylamine → HCID 68698119, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the phenol product obtained from step 6 of Example 3 (0.38 g, 1.0 mmol) and diisobutylamine (18 μL, 0.10 mmol) in toluene (5 mL) was added dropwise sulfuryl chloride (80 μL, 1.0 mmol) over 10 min. The resulting solution was stirred at 25° C. for 1 h and then quenched with a saturated solution of aqueous sodium bicarbonate. The organic layer was extracted with ethyl acetate and the combined organic layer was washed with 2 N solution of sodium sulfite. After removal of the solvent, the crude product was purified by chromatography on silica gel eluting with 7:3 hexane:ethyl acetate to give the title product as a solid.

Provenance & Evidence