Acetic Acid → HCID 11846909, compound

Participants

Reaction Steps

The ester from Step 1 (2.3 g, 4.5 mmol) was dissolved in methanol (45 mL) and treated with 2 N NaOH (4.5 mL, 9.0 mmol) at room temperature for 1 h. The reaction mixture was acidified with acetic acid (2.0 mL) and methanol was removed under reduced pressure. The residue was taken up in ethyl acetate and the resulting solution was washed with brine and dried over MgSO4. After removal of the solvent, the crude acid was recrystallized in ether-hexane (1:10) to give the title product as a white solid.

Provenance & Evidence