Trifluoroacetic acid → HCID 11960590, compound

Participants

Reaction Steps

To a solution of benzyl({2-[({2-[(tert-butoxycarbonyl)amino]phenyl}amino)carbonyl]-1-benzothien-6-yl}methyl)carbamate (85 mg, 0.16 mmol) in CH2Cl2 (4 mL) was added TFA (2 mL). The reaction mixture was stirred for 2 h, the solvent was removed. The residue was triturated with CH2Cl2 and sat. NaHCO3, and the resultant solid was filtered yielding the desired product. 1H NMR (DMSO-d6, 600 MHz) δ 10.05 (br s, 1H), 8.23 (s, 1H), 7.87 (m, 2H), 7.80 (s, 1H), 7.32-7.29 (m, 4H), 7.27 (m, 1H), 7.17 (br d, J=6.8 Hz, 1H), 7.02 (dd, J=6.8, 6.8 Hz, 1H), 6.87 (br d, J=6.8 Hz, 1H), 6.75 (br s, 1H), 5.00 (s, 2H), 4.29 (d, J=6.2 Hz, 2H). MS: cal'd 432 (MH+), exp 432 (MH+).

Provenance & Evidence