Thionyl Chloride → 3-Chloroisonicotinoyl chloride

HRID 1172922Notes

Reaction equation

HRID 1172922 reaction equation
[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:13])=O>>[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:13])=[O:5]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 27358163-Chloropyridine-4-carboxylic acid

Product 1

HCID 204874993-Chloroisonicotinoyl chloride

Procedure

To 3-chloroisonicotinic acid (413 mg, 2.62 mmol) was added thionyl chloride (5 mL, 68.5 mmol). The reaction mixture was stirred at room temperature for about 20 hours. The solution was concentrated under reduced pressure and the residue was dried under high vacuum for 1 hour to give 3-chloro-isonicotinoyl chloride.

Workup

  1. concentrationThe solution was concentrated under reduced pressure
  2. customthe residue was dried under high vacuum for 1 hour

Sources & evidence

ORD record
ord-e99f5a143b374b318ac8629b9643d607
Source dataset
uspto-grants-2010_11
Patent number
US07834039B2

Reaction notes

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